imidazoleacetic acid - PMC

Katarzyna Gałczyńska, Karol Ciepluch, Łukasz Madej, Krystyna Kurdziel, Barbara Maciejewska, Zuzanna Drulis-Kawa, Aneta Węgierek-Ciuk, Anna Lankoff, Michał Arabski

Sci Rep. 2019; 9: 9777. Published online 2019 Jul 5. doi: 10.1038/s41598-019-46224-6

PMCID:: PMC6611867

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Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

Shen-Han Lee, Dominick McIntyre, Davina Honess, Alzbeta Hulikova, Jesús Pacheco-Torres, Sebastián Cerdán, Pawel Swietach, Adrian L. Harris, John R. Griffiths

Br J Cancer. 2018 Aug 28; 119(5): 622–630. Published online 2018 Sep 12. doi: 10.1038/s41416-018-0216-5

PMCID:: PMC6162214

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Select item 42065278.

Reproducible Automated Phosphopeptide Enrichment Using Magnetic TiO₂ and Ti-IMAC

Christopher J. Tape, Jonathan D. Worboys, John Sinclair, Robert Gourlay, Janis Vogt, Kelly M. McMahon, Matthias Trost, Douglas A. Lauffenburger, Douglas J. Lamont, Claus Jørgensen

Anal Chem. 2014 Oct 21; 86(20): 10296–10302. Published online 2014 Sep 18. doi: 10.1021/ac5025842

PMCID:: PMC4206527

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Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

Zihao Wang, Marjan Gucek, Gerald W. Hart

Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37): 13793–13798. Published online 2008 Sep 8. doi: 10.1073/pnas.0806216105

PMCID:: PMC2544533

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Optimizing TiO₂-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry

Greg T. Cantin, Teresa R. Shock, Sung Kyu Park, Hiten D. Madhani, John R. Yates, III

Anal Chem. Author manuscript; available in PMC 2008 Sep 12.

Published in final edited form as: Anal Chem. 2007 Jun 15; 79(12): 4666–4673. Published online 2007 May 25. doi: 10.1021/ac0618730

PMCID:: PMC2535607

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An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers

Joseph E. Ippolito, Jian Xu, Sanjay Jain, Krista Moulder, Steven Mennerick, Jan R. Crowley, R. Reid Townsend, Jeffrey I. Gordon

Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28): 9901–9906. Published online 2005 Jul 5. doi: 10.1073/pnas.0500756102

PMCID:: PMC1169236

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Select item 181668112.

Identification of Histamine Metabolite 1-methyl,4-imidazole Acetic Acid in Human Urine and its Absence in Status Asthmaticus

James W. Kerr

Br Med J. 1964 Sep 5; 2(5409): 606–608. doi: 10.1136/bmj.2.5409.606

PMCID:: PMC1816681

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Select item 1073023513.

Cotton Ti-IMAC: Developing Phosphorylated Cotton as a Novel Platform for Phosphopeptide Enrichment

Danqing Wang, Junfeng Huang, Haoran Zhang, Ting-Jia Gu, Lingjun Li

ACS Appl Mater Interfaces. Author manuscript; available in PMC 2023 Dec 19.

Published in final edited form as: ACS Appl Mater Interfaces. 2023 Oct 18; 15(41): 47893–47901. Published online 2023 Oct 9. doi: 10.1021/acsami.3c08697

PMCID:: PMC10730235

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A Membrane‐Permeable and Immobilized Metal Affinity Chromatography (IMAC) Enrichable Cross‐Linking Reagent to Advance In Vivo Cross‐Linking Mass Spectrometry

Pin‐Lian Jiang, Dr. Cong Wang, Dr. Anne Diehl, Dr. Rosa Viner, Dr. Chris Etienne, Dr. Premchendar Nandhikonda, Leigh Foster, Dr. Ryan D. Bomgarden, Prof. Dr. Fan Liu

Angew Chem Int Ed Engl. 2022 Mar 14; 61(12): e202113937. Published online 2022 Jan 27. doi: 10.1002/anie.202113937

PMCID:: PMC9303249

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Rat α₆β₂δ GABA_A receptors exhibit two distinct and separable agonist affinities

Stephen H Hadley, Jahanshah Amin

J Physiol. 2007 Jun 15; 581(Pt 3): 1001–1018. Published online 2007 Mar 29. doi: 10.1113/jphysiol.2007.132886

PMCID:: PMC2170852

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Select item 157512116.

Peripheral GABA_B agonists stimulate gastric acid secretion in mice

Laura Piqueras, Vicente Martinez

Br J Pharmacol. 2004 Jul; 142(6): 1038–1048. Published online 2004 Jun 21. doi: 10.1038/sj.bjp.0705876

PMCID:: PMC1575121

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GABA_A and GABA_C receptors in adult porcine cones: evidence from a photoreceptor–glia co-culture model

Serge Picaud, Bikash Pattnaik, David Hicks, Valérie Forster, Valérie Fontaine, José Sahel, Henri Dreyfus

J Physiol. 1998 Nov 15; 513(Pt 1): 33–42. doi: 10.1111/j.1469-7793.1998.033by.x

PMCID:: PMC2231280

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Select item 198699918.

Determination of imidazole acetic acid and its conjugate(s) levels in urine, serum and tissues of rats: studies on changes in their levels under various conditions.

I. Imamura, K. Maeyama, H. Wada, T. Watanabe

Br J Pharmacol. 1984 Jul; 82(3): 701–707. doi: 10.1111/j.1476-5381.1984.tb10809.x

PMCID:: PMC1986999

Summary Page Browse PDF–867K

Select item 190738019.

Distribution and cellular localization of imidazoleacetic acid-ribotide, an endogenous ligand at imidazol(in)e and adrenergic receptors, in rat brain

Victor L. Friedrich, Jr., Giorgio P. Martinelli, George D. Prell, Gay R. Holstein

J Chem Neuroanat. Author manuscript; available in PMC 2008 Jan 1.

Published in final edited form as: J Chem Neuroanat. 2007 Jan; 33(1): 53–64. Published online 2007 Jan 8. doi: 10.1016/j.jchemneu.2006.11.002

PMCID:: PMC1907380

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Select item 673441020.

Vestibular neurons with direct projections to the solitary nucleus in the rat

Amelia H. Gagliuso, Emily K. Chapman, Giorgio P. Martinelli, Gay R. Holstein

J Neurophysiol. 2019 Aug 1; 122(2): 512–524. Published online 2019 Jun 5. doi: 10.1152/jn.00082.2019

PMCID:: PMC6734410

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Figure 1

Specificity of the purified anti-IAARP antibody. A: Anti-IAA-RP binding to wells of ELISA plates coated with various BSA conjugates. The antiserum showed strong binding to IAA-RP-BSA and negligible activity against conjugates of related compounds (IAA-R: imidazoleacetic acid riboside; AICAR-P: 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate; IAA: imidazoleacetic acid; ATP: adenosine triphosphate; AMP: adenosine monophosphate). B: Binding of a single dilution of anti-IAA-RP serum to IAA-RP-BSA-coated wells assayed in the presence of various concentrations of putative competitors. Only IAA-RP inhibited the binding; all other competitors tested showed little or no activity.

Distribution and cellular localization of imidazoleacetic acid-ribotide, an endogenous ligand at imidazol(in)e and adrenergic receptors, in rat brain

J Chem Neuroanat. ;33(1):53-64.
Figure 4

Synthesis and degradation of histamine: Histamine is formed by the decarboxylation of HIS by L-histidine decarboxylase (EC 4.1.1.22) found in many tissues. Released histamine is degraded to 1,4-methyl imidazoleacetic acid; the second pathway of histamine degradation is oxidation to imidazoleacetic acid. The metabolites are released in the urine or processed to other metabolites. 1, histidine decarboxylase; 2, histamine-N-methyltransferase; 3, monoamino oxidase; 4, aldehyde dehydrogenase; 5, diamino oxidase.

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

Nutrients. 2020 Mar;12(3):848.
FIGURE 5

Correlation analysis of metabolic biomarkers and Th1, Th2, Treg, Th17 cells in OVA induced eosinophilic asthma model. (A) Correlation plot showing the relationship between the differential metabolites in plasma and the key immune indicators of eosinophillic asthma including OVA-IgE, Penh value and eosinophil number in BALF. (B) Biomarkers of metabolic biomarkers in eosinophilic asthma associated with Th1, Th2, Treg and Th17 cells, followed by Malate, l-dihydroorotate, Imidazoleacetic acid and 1,5-anhydro-d-sorbitol. *p < 0.05, **p < 0.01, ***p ≤ 0.001. All the values are expressed as mean±SEM. n = 7 animals per group.

Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma

Front Pharmacol. 2022;13:819747.
Fig. 8.

Presence of the neuromodulator imidazoleacetic acid ribotide (IAA-RP) in vestibulo-solitary projections. Each panel comprises a main image with the neuron of interest indicated by a solid arrow, with channel separations demonstrating the individual immunolabels on right. A: IAA-RP is present in a glutamate- and Fluoro-Gold-immunofluorescent neuron in the inferior vestibular nucleus (DVN) (solid arrow) ipsilateral to the tracer injection. B: IAA-RP, glutamate, and Fluoro-Gold coexistence in a neuron in ipsilateral medial vestibular nucleus (MVN) (solid arrow). Dashed arrows, additional examples of IAA-RP-labeled Fluoro-Gold-positive neurons. C and D: IAA-RP and Fluoro-Gold coexistence in neurons that do not display GABA immunoreactivity but are surrounded by GABAergic puncta (arrows). C is from ipsilateral MVN and D from contralateral DVN. All scale bars, 10 µm.

Vestibular neurons with direct projections to the solitary nucleus in the rat

J Neurophysiol. 2019 Aug 1;122(2):512-524.